Indica vs. sativa vs. hybrid: what’s the difference?

Medically Reviewed by: Dr. Caley Scott, ND

The terms indica, sativa, and hybrid are often used to describe cannabis, but the differences are not as straightforward as many assume. Historically, these labels referred to plant morphology. Indica plants were shorter and bushier, and sativa plants were taller and narrower. 

Today, the actual effects depend more on chemotype (the balance of cannabinoids and terpenes) and individual biology than on plant shape. In other words, chemistry and serving size matter more than labels.

Quick answer

Indica strains are traditionally linked with relaxation, while sativas have uplifting and energy-boosting effects. Hybrids are thought to be a blend of effects from both the indica and sativa categories, but this isn't necessarily true. 

Effect profiles depend far more on cannabinoid ratios (THC/CBD), terpene blends, and your own unique biology..

What are cannabis strains?

Cannabis strains are subtypes of a species, similar to a breed. They’re different types of the same plant, and some people may significantly prefer one’s effects over the other. 

Blueberry and Haze, for example, work differently, but they’re both cannabis. They can be bred together (to make the beloved hybrid strain Blue Dream) to balance the strongest traits. Someone might find that Blueberry is a better fit for their needs than Haze, or vice versa. 

There is technically the potential for a nearly unlimited amount of cannabis strains. Currently, there are about 700 distinctly recognized strains of cannabis, and each strain has a unique balance of cannabinoids and terpenes, which is what makes them distinct from one another. 

Terpenes specifically impact cannabis properties and change the trajectory of the cannabis experience. While some terpenes are known for supporting sleepiness, others are known for the energizing feelings they bring.* 

What is indica?

Cannabis indica is a type of cannabis plant that grows short and stout, kind of like a hedge or a bush. The leaves are broad, flat, and blunted at the ends. Cannabis indica is believed to have originated in the Hindu Kush mountains north of Afghanistan and Pakistan, which is why many strains have the word “kush” in their name. It denotes the origin of the strain or the strain’s parents.

Cannabis indica’s unique shape and structure allow it to thrive in dry, arid climates like mountain ranges. Its short, bushy stature and tendency to grow close to the ground makes it easier for the plant to trap and retain water in areas where rain may be scarce.

Cannabis indica also thrives at high elevation. The highest peak of the Hindu Kush mountain range, Tirich Mir, sits at over 25,000 feet—this is a comparable height to Mount Everest, and it’s much closer to the sun. Damaging UV rays can scorch the leaves of tall plants, and Cannabis indica’s shorter stature allows it to avoid some UV damage.

Cannabis indica is now cultivated all over the world, both indoors and outdoors. Cannabis indica has been used for over 5,000 years, and its seeds have extensively traveled the globe. You can find feral (wild) cannabis in almost every country.

How does indica make you feel?

Most people seek Cannabis indica for its sedative effects.* Many people report that indica makes them feel sleepy. This is a common occurrence with strains that produce a “body high,” where the sensations in your body change, and your limbs may feel heavy.

Indica is generally recommended to relieve discomfort, support sleep, and support a calm mood. People may choose indica strains for sedentary activities, like movie nights at home, creating art, or journaling, for example. 

Indica may not make you feel the same way it makes other people feel, however. Technically speaking, terpenes would be the main reason as to why Cannabis indica would have sedative properties and Cannabis sativa would not. They usually contain the same cannabinoids, sometimes in similar ratios or balances. 

The effects, benefits, and experiences you may have when you use a particular strain are more likely related to the strain itself. It may not matter whether the strain is indica or sativa. It’s an individualized experience, and the only way to know for sure how indica will make you feel is to try it yourself.

What is sativa?

Cannabis sativa and Cannabis indica aren’t different types of cannabis; they’re both the same plants, but they’ve adapted to favor specific traits that allowed them to thrive in the wild. 

Cannabis sativa plants are usually very tall and thin, like palm trees, with many leaves growing from the trunk. Cannabis sativa plants can grow as high as 20 feet tall, double the height of a standard basketball hoop. The leaves of a sativa plant are long, thin, and pointy. Most cannabis iconography uses the shape of the sativa leaf rather than the indica leaf. 

Cannabis sativa originated in Central Asia, and evidence suggests that Cannabis sativa has been used in folk remedies for over 12,000 years. At this point in history, humans were just starting to practice agriculture to eliminate the need for hunting and gathering. 

Cannabis sativa plants are native to central Asian woodlands along several river systems. They likely adapted to grow tall and thin to compete for light when growing under the shade of larger shrubs or trees. 

How does sativa make you feel?

Most people describe Cannabis sativa as energizing, uplifting, or euphoric.* The feeling is often described as a head high. It may make you feel happy, talkative, or giggly. Sativa strains are generally regarded as less sedating and more stimulating. 

Some people say that sativa helps to improve their focus or creativity. Many musicians report choosing sativa strains over indica strains when they’re writing music or performing. People tend to choose sativa strains when they have something to do, like a social gathering or a project around the house. 

Your experience with sativa strains may be vastly different. To notice a difference in the way certain strains affect you, this usually requires gaining experience using both sativa and indica. 

Generalizations may give you a good idea of what to expect, but you won’t know the exact feeling until you’ve tried a strain for yourself. 

What is hybrid cannabis?

Hybrid cannabis is cannabis that has both Cannabis indica and Cannabis sativa in its genetic lineage. With that in mind, almost all strains of cannabis are technically hybrids—cannabis plants have been transported across the world and crossbred since long before cannabis growers were keeping track of genetics and lineage. It’s possible that no true sativa or true indica strain currently exists. 

Hybrid cannabis doesn’t have a specific origin because humans cultivate it—growers choose two strains with excellent traits or genetics and breed the plants together to cultivate a better balance of cannabinoids and terpenes, or to enhance the potential for certain effects. 

In many ways, hybrid cannabis strains are among the best. Knowledgeable growers have worked with nature to custom cultivate cannabis plants to address specific wellness needs, which nature takes much longer to do on its own.* 

How does hybrid cannabis make you feel?

Hybrid cannabis strains don’t have a set profile of effects, as they vary significantly with each specific strain. The effects of a strain likely relate directly to its terpene profile and cannabinoid balance, including how the two interact.*

Prominent cannabis researchers postulate that the potential unique effects of cannabis strains relate to something called the entourage effect. The entourage effect is the theory that all of the cannabinoids and terpenes work together in synergy to create a distinct effect profile.* 

Hybrid strains can be energizing or sedating, and they can give you more of a head high or more of a body high. It’s likely a strain-specific experience.*

Does indica or sativa have more THC?

There is a widespread belief that indica strains are higher in CBD and lower in THC, while sativa strains are lower in CBD and higher in THC. This belief is based on folk knowledge rather than actual science, and it isn’t necessarily true.

Both sativa and indica can be bred to produce very high or very low amounts of THC. Indica strains like Granddaddy Purple and Hindu Kush can contain more than 20% THC, which would be considered very high. Sativa strains like Harlequin are bred to contain 10% CBD and 5% THC. This disproves the idea that one type of cannabis contains more THC than another type—generally speaking.

Does CBD come from indica or sativa?

CBD (cannabidiol) is a major cannabinoid that occurs in all cannabis plants. Most breeders of recreational cannabis prefer to prioritize THC content over CBD content and will breed plants that favor high THC production. 

Breeders of cannabis plants designated for wellness products often do the opposite: they’re more interested in CBD's therapeutic effects than THC's psychoactive effects and will cultivate plants to favor CBD and minor cannabinoid production.

The majority of CBD grown for wellness products doesn’t come from traditional cannabis—instead, it comes from hemp, which is any Cannabis sativa plant with less than 0.3 percent THC by dry weight. This is more of a matter of convenience than a necessity since Cannabis indica plants also possess the ability to produce large amounts of CBD.*

Is hemp considered a cannabis strain?

Hemp isn’t a cannabis strain or a different type of plant. It’s a term used to describe cannabis plants that meet the required specifications to be grown legally. 

Industrial hemp is a very valuable crop that can be used to make sustainable versions of things we use every day, like paper and textiles. Its value was too great to pass up, especially at a time where the need for environmental sustainability is more important than ever. 

The FDA and United States government allowed any cannabis plant that produces 0.3% THC or less by its dry weight to be named hemp. Hemp plants are federally legal to grow as long as growers hold a valid hemp license (which is often free) and pass a background check. 

Are there different types of hybrid cannabis?

Popular hybrid strains like Gelato and Blue Dream have an almost perfectly even balance of sativa and indica lineage. Most hybrids will have either more sativa or more indica. Strains that slightly favor one type of lineage will be called indica-dominant hybrids or sativa-dominant hybrids.

Indica vs. sativa vs. hybrid at a glance: a comparison table

You have hundreds of choices to make when you’re choosing a strain of cannabis that will work best for you. These chances all fall under three umbrellas. 

The first step in finding the perfect strain of cannabis for your wellness needs is to decide which category sounds most appealing. 

Traits and Uses	Indica	Sativa	Hybrid
Daytime vs. nighttime use	Often chosen for evening or nighttime relaxation routines.	Commonly used in daytime for focus or creativity.	Flexible and dependent on dominant parent traits.
Commonly reported effects	Traditionally calming, felt throughout the body, sometimes drowsy.	Traditionally uplifting, felt in the mind, energizing.	Mixed. May lean relaxing, stimulating, or a combination of the two.
Historical plant traits	Short, broad leaves, and dense buds. Adapted to colder climates.	Tall, narrow leaves, and fluffy buds. Adapted to warm climates.	Cross-bred with traits from both parents.
Chemotype tendencies	Sometimes higher CBD/THC balance, but this varies widely by cultivar.	Often THC-dominant, but this isn't always the case.	Variable and depends on lineage and breeding.
Common terpenes	Myrcene, linalool, beta-caryophyllene.	Limonene, pinene, terpinolene.	Any mix. Terpenes mirror genetics and breeding goals. Hybrids are usually bred for interesting terpene profiles.
When to consider the strain	Looking for restful, calming experiences.	Seeking motivation, daytime use, or social energy.	When you want tailored effects, not strictly sedating or energizing.
Potential drawbacks	Sedation, “couch lock,” dry mouth.	Can feel racy or anxious in high THC amounts.	Effects may be unpredictable or inconsistent.
Popular varieties	Granddaddy Purple, Northern Lights.	Durban Poison, Jack Herer.	Blue Dream, Wedding Cake.

Disclaimer: Labels suggest tendencies but do not guarantee specific effects. Always check cannabinoid and terpene content on a certificate of analysis for the batch of cannabis you're purchasing.

How to choose between indica, sativa, and hybrid strains

When selecting between indica, sativa, or hybrid, focus less on the label and more on your goals and the chemistry of individual strains. Here’s a framework.

Sleep and relaxation

Some people exclusively use cannabis at night as a core part of their unwinding ritual. You have a little more freedom exploring strains while you’re at home and have nothing important to do. Experimentation is safer when you plan on staying in for the rest of the night.

• Goal: Support rest and winding down.
• Cannabinoids: Balanced THC:CBD (1:1) or CBD-dominant can be gentler than high-THC strains.
• Terpenes: Look for myrcene, linalool, beta-caryophyllene.
• Serving sizes: Start low; edibles take one to two hours before bed, tinctures about 30-45 minutes before bed. Inhalables work faster, but they're shorter-lasting.
• Safety: Avoid driving or engaging in important tasks. Respect local laws.

Although pre-bedtime use gives you a little more freedom, you should still be careful. Remember that you can always use more cannabis if you feel it necessary to do so, but you can’t stop the cannabis you’ve already used from working. 

Start low and assess how you feel before increasing your serving size.

Focus and energy

Some people use cannabis to inspire creative breakthroughs or to find motivation. Daytime cannabis use requires special caution, particularly if you’ll need to go out and interact with the world at some point throughout the day.

• Goal: Enhance productivity or creativity.
• Cannabinoids: THC-dominant, but avoid very high levels if you're prone to anxiety.
• Terpenes: Limonene, pinene, terpinolene.
• Serving size: Small amounts may be energizing, but large serving sizes may cause sedation.
• Safety: Don’t combine with tasks requiring precision, like driving.

Starting low is key to avoiding unpleasant experiences that can come with daytime cannabis experimentation.

Mood and tension

Cannabis can be used as a natural source of mood support while providing support to the body’s stress response. Start low and go slow when determining if cannabinoids can benefit your overall emotional well-being.

• Goal: Lighten mood, support calm presence.
• Cannabinoids: Balanced THC:CBD or CBD-dominant formulas are often well-tolerated.
• Terpenes: Linalool, limonene, beta-caryophyllene.
• Serving size: Microdosing (very small amounts) is sometimes preferred.
• Safety: Seek professional advice if on medications.

Some people find that cannabinoids can exacerbate unwanted feelings. If you feel like cannabis increases your stress levels or worsens your mood, plain CBD may be a better fit.

Physical comfort

Cannabis may ease physical discomfort in some people. It can be useful in the context of your comfort level in two ways: you can use ingestible forms of cannabis or topical forms of cannabis. Your body uses both forms differently.

• Goal: Support everyday body ease.
• Cannabinoids: Balanced or THC:CBD ratios; sometimes higher THC preferred by experienced users.
• Terpenes: Myrcene, humulene, beta-caryophyllene.
• Seving size: You can use topicals for localized muscle discomfort, and they won't interact with other forms of cannabis. You can use them in conjunction with ingestibles for broader systemic effects.
• Safety: Be mindful of onset time. You can dial in when to receive support when you'll need it.

If you’re only interested in addressing a specific concern, like a tense muscle, you may be able to skip other forms of cannabis entirely and exclusively use cannabis topical creams on the affected area.

First-timers / low THC

Finding the perfect serving size is a game of trial and error. The goal is to avoid as many errors as possible. By taking a low and slow approach, you’re more likely to find the ideal serving size without feeling overwhelmed by the effects of potent cannabis.

• Goal : Explore cannabis gently.
• Cannabinoids : Start with CBD-dominant or balanced ratios.
• Terpenes : Opt for mild terpene balance and avoid ultra-potent strains.
• Serving size : “Start low and go slow.” Begin with 2-5 mg THC if you're using a THC product.
• Safety : Always check COAs and legal status.

Budtenders can be incredibly helpful for first-timers who aren’t sure where to start. Don’t be afraid to ask your local budtender questions about what effects you’re hoping to experience.

Discrete use/daytime

Discrete daytime cannabis use can be tricky, especially if you have a busy life that demands a lot of you during daytime hours. It’s important to be mindful of how you choose to use cannabis throughout the day.

• Goal : Subtle, clear-headed daytime support.
• Cannabinoids : CBD-dominant, or balanced low-THC.
• Terpenes : Limonene, pinene, for subtle flavor and aroma.
• Serving size : Tinctures or capsules are discreet. Vapor, due to its appearance and aroma, can draw a lot of attention.
• Safety : Avoid psychoactive products if working or socializing publicly.

Remember that safety and responsibility are crucial for daytime cannabis use.

Indica, sativa, and hybrid labels are shorthand, not science. When in doubt, read the COA. Look for cannabinoid percentages, THC:CBD ratios, and terpene profiles.

What to know about indica and sativa legality

The legality of cannabis hinges significantly on its THC content, the primary psychoactive compound. Under the 2018 Farm Bill in the United States, hemp is legally defined as cannabis plants containing less than 0.3% THC by dry weight, making it federally legal to cultivate and sell. This classification applies to both indica and sativa strains if they meet the THC threshold. 

However, cannabis plants with THC levels exceeding 0.3% are classified as marijuana and are subject to federal regulations and varying state laws. While some states have legalized marijuana for medical or recreational use, others continue to enforce strict prohibitions. 

This legal distinction affects growers, distributors, and consumers of Indica and Sativa strains, influencing their availability and the legal implications of their use. It's important for individuals to be aware of their local laws regarding THC content to ensure compliance when cultivating or consuming cannabis products.

Do indica and sativa have side effects?

All forms of cannabis can have side effects, and if one strain of cannabis causes any of these side effects for you, many other strains of cannabis will likely cause the same.

Some common side effects of cannabis include:

• Nausea
• Dry mouth
• Dry eyes
• Increased hunger or thirst
• Lightheadedness
• Fatigue
• Dizziness
• Drowsiness
• Difficulty concentrating
• Strange dreams
  
  

These side effects will go away on their own as cannabis leaves your system. Side effects are usually more severe if you consume very high THC content which is why it’s important to start low and go slow. You can’t make the effects of cannabis stop after you’ve used it—but you can use more cannabis if you feel the effects aren’t strong enough. Be sure to note that inhaling THC is the fastest way to notice the "high", while delivery methods like gummies can take up to an hour to kick-in. 

How can you pick the right strain for your needs?

If you’re new to cannabis, figuring out where to start can be difficult. The number of options can be overwhelming, and you may not know what questions you should ask the staff at your local dispensary. Here’s how to narrow your search and find strains you’re likely to enjoy.

Establish your wellness goals

Even if you’re only interested in using cannabis recreationally, you probably have a good idea of how you’d like to feel. Do you want a relaxing experience? Are you looking for creative inspiration? Are you hoping that cannabis will help you feel more sociable? 

Jot down how you’d like to feel and use that to explore strains that commonly impart those effects.

Experiment with terpenes and cannabinoids

If you’ve never used cannabinoids, you need to know how they affect you. 

Our delta-8 and delta-9 blend live resin-infused gummies will allow you to experience the effects of low THC. You can narrow down your search by trying our sativa live resin gummies and our indica live resin gummies, which may give you a better idea of how different strains may work for you. 

You can experiment with terpenes by smelling essential oils. The aromatic compounds in cannabis are identical to the aromatic compounds that make essential oils fragrant. For example, limonene is found in lemon essential oil. Caryophyllene can be found in black pepper essential oil. Ocimene is found in mint, pinene is found in pine, linalool is found in lavender, myrcene can be found in juniper... the list goes on.

“The nose knows” is a popular expression in cannabis circles, and it means you can simply tell how a strain might affect you by smelling it. By smelling essential oils and contemplating how they make you feel, you’ll be able to establish a starting point for your search. 

If you know that limonene gives you the uplifting feeling you’re looking for, choose strains high in limonene. If the serene and soothing aroma of lavender appeals most to you, choose strains high in linalool. 

Record your experiences

After you try a strain of cannabis, record how it makes you feel. What did you like? What do you wish would have been different? Was it a positive, negative, or neutral experience? 

Keeping track can help steer you in the right direction, and when you return to the dispensary or another cannabis/hemp provider, you’ll have a better idea of what questions to ask your budtender.

Your budtender will be able to recommend strains similar to the ones you prefer and help you avoid strains similar to the ones you weren’t happy with.

Explore cannabis genetics 

When you find a strain you like, exploring the strain’s genetics can lead you to more strains you might enjoy. Every strain of cannabis has a large family tree. Strains even have parents and half-siblings. 

Trying parent strains of a strain that you enjoyed can help you pinpoint exactly what you liked about it. Trying half-sibling strains may give you similar experiences.

The bottom line

Cannabinoid research is relatively new. Most of the information circulated about cannabis comes from anecdotal experiences rather than scientific research. There are a lot of misconceptions about the differences between sativa, indica, and hybrid strains. The truth is much more nuanced. 

You shouldn’t limit yourself to indica or sativa cannabis if you’re seeking specific effects. Effects are more likely to be strain-specific rather than specific to the type of cannabis you choose. If you’re interested in the way that the effects of cannabinoids may impact your wellness, you can shop our collection of products. Remember, if you are new to THC, start low and slow. Start with a hemp supplement with low THC and you might find exactly what you're looking for. 

FAQs

Which has more THC: indica or sativa?

Neither consistently. THC levels are determined by the cultivar’s genetics and breeding, not its label. There are high and low THC strains in every category, so you cannot reliably assume that indica or sativa would be inherently more potent. Always check the COA to know the actual potency.

Which is better for sleep?

Many consumers reach for indica varieties because of their reputation for relaxation, but effectiveness depends more on cannabinoid ratios and terpenes like myrcene or linalool. Balanced THC:CBD or CBD-forward profiles can support rest without having overwhelming psychoactive effects. The serving size matters just as much as type.

Are most modern strains hybrids?

Yes. Centuries of cross-breeding mean that pure landrace indica and sativa varieties are rare in today’s market. Most products are hybrids, leaning indica-dominant or sativa-dominant, with characteristics drawn from both lineages.

Does CBD come from indica or sativa?

CBD can be found across cannabis varieties. Some indica and sativa cultivars express higher CBD levels, but legally defined “hemp” refers to cannabis bred with ≤0.3% THC by dry weight, regardless of its indica or sativa appearance.

Is hemp indica or sativa?

Hemp is legally classified, not botanically limited. Many hemp plants are catalogued as Cannabis sativa L., but the key distinction is THC content (≤0.3%). Hemp’s effects depend on its cannabinoid and terpene chemistry, not its botanical label.

Is “indica = in-da-couch” accurate?

It’s a memorable rule of thumb, but not a scientific truth. Some indicas feel sedating, but others do not. Likewise, some sativas may feel calming. Actual effects are driven by cannabinoid content, terpene mix, and your personal response. There are plenty of people who enjoy indica strains that people would consider hard-hitting, and they have no trouble cleaning their house or doing their laundry. 

Sources:

Therapeutic and Medicinal Uses of Terpenes | PMC

Indica and sativa labels are largely meaningless when it comes to cannabis complexities - Dal News | Dalhousie University

Medicinal Cannabis: History, Pharmacology, And Implications for the Acute Care Setting | PubMed Central | National Institutes of Health

History of cannabis and the endocannabinoid system | PubMed Central | National Institutes of Health

The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain | Frontiers in Plant Science

FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD) | FDA

A classification of endangered high-THC cannabis (Cannabis sativa subsp. indica) domesticates and their wild relatives | PMC

The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD | PMC

2018 Farm Bill