CBN and melatonin: Can you take them together?

Learn the key benefits of CBN and whether or not you should take it with melatonin.

CBN and melatonin: Can you take them together?
minute read

Sleep is one of the most natural, restorative aspects of the human experience — at least, it should be. Yet, many people struggle to get the rest they need. The search for better sleep often leads to supplements and sleep aids, such as CBN (cannabinol) or melatonin. While both are popular options for sleep support, they function differently in the body, offering unique benefits and considerations. 

Understanding how each works can help you make informed decisions to enhance your sleep quality. We’re here to set the record straight and give you the breakdown of these common compounds. 

What is CBN?

CBN, short for cannabinol, is a minor cannabinoid found in the cannabis plant. It develops as THC (tetrahydrocannabinol) degrades over time, forming a compound with its own unique properties. 

Unlike THC, CBN does not produce psychoactive effects, meaning it won’t isn’t intoxicating and won’t alter the mental state.*

CBN interacts with the body through the endocannabinoid system (ECS), a complex network of receptors and enzymes that helps regulate functions like sleep, mood, and stress response. 

Specifically, CBN engages with CB1 and CB2 receptors, which are found throughout the brain and body.* This interaction supports processes that help prepare the body for restful sleep by promoting relaxation and easing tension.*

The effects of CBN tend to be more physically soothing rather than mentally stimulating, as the compound targets CB2 receptors more heavily than CB1.*

Studies suggest that CBN’s calming effects can support sleep quality without the grogginess associated with some traditional forms of sleep support. It’s most effective when used consistently as part of a comprehensive approach to managing sleep and improving well-being over time.*

What makes CBN different from CBD?

It’s common to group CBN with CBD (cannabidiol) since both are derived from the cannabis plant, but they work differently. While CBD is known for its broader impact on emotional wellness and everyday discomfort, CBN is more specialized in promoting relaxation and addressing issues tied to poor sleep duration.*

Unlike CBD, which can be used any time of day, CBN is better suited for evening routines because of its ability to help the body transition into a restful state. Products like CBN gummies and tinctures are tailored to support sleep improvement in a targeted, gentle way without the risk of developing a dependency.*

How does melatonin work?

Melatonin is a natural hormone produced in the body by the pineal gland in the brain. It plays a key role in regulating the body’s circadian rhythm, which helps align the sleep-wake cycle with natural light and darkness. As evening sets in, melatonin levels rise, signaling the body that it’s time to sleep.

This hormone is synthesized from the amino acid tryptophan, and darkness triggers its release. This process allows the body to synchronize with daily environmental changes, ensuring consistent, high-quality sleep patterns.

Why do people take melatonin supplements?

If melatonin is secreted naturally by the brain at night, why is this such a popular sleep aid supplement in our modern world? The answer is this simple: people aren’t getting the sleep they need, so they turn to exogenous forms of melatonin to help.

Taking melatonin can manipulate the body's natural circadian rhythm and help you fall asleep, even if you aren’t tired at the end of the day. Those with jet lag or sleeping troubles may find melatonin useful when it comes time to reset their sleep cycle and catch up on sleep debt.

This isn’t inherently a bad thing — there are worse ways to induce sleep. However, taking external sources of endogenous hormones can backfire over time, as the body loses its ability to produce them independently. Melatonin is also known to cause unwanted side effects, making for an unsustainable daily routine. That’s why Sunmed recommends using CBN and practicing other forms of sleep hygiene to achieve natural, sustainable, and consistently effective sleep support.

What are the key differences between CBN and melatonin?

Although both CBN and melatonin can improve sleep quality, they operate in very different ways. Let’s break down some of their biggest differences.

Mechanism of action

CBN works by interacting with the ECS to promote relaxation and support processes that encourage restful, uninterrupted sleep.

Melatonin directly influences the body’s circadian rhythm by mimicking the natural rise in melatonin levels during the evening.

Short-term vs. long-term use

CBN is suitable for regular use without disrupting the body’s natural functions, offering a sustainable approach to sleep support.

Melatonin is effective for short-term needs, but frequent use may reduce the body’s ability to produce melatonin naturally.

Potential side effects

CBN has minimal side effects, with a focus on supporting natural hormone balance and reducing physical tension. Taking at night and using high-quality, third-party tested CBN products and taking the suggested doses of CBN as stated on your product can further help limit any potential side effects, such as lethargy or nausea.

Side effects of melatonin may include grogginess, drowsiness, and brain fog, especially when taken in high doses or inconsistently. Studies also found that up to 88% of over-the-counter melatonin products are labeled incorrectly. The report shows that some products contain more melatonin than is reported on the label, meaning users are ingesting far more than intended.

Why choose CBN for sleep?

At its core, CBN is a natural compound that supports your body’s systems rather than replacing them. Its interaction with the ECS promotes balance and relaxation in a way that complements your body’s natural rhythms.* Unlike synthetic melatonin supplements, CBN supports long-term health goals, offering a sustainable path to better sleep.

For those dealing with sleep disturbances or seeking a gentle, non-psychoactive solution, CBN provides a powerful, science-backed option. Whether you’re new to cannabinoids or exploring alternatives to traditional sleep aids, CBN can be a key part of your routine for restful sleep and well-being.*

CBN is available in a range of formulations, including CBN gummies, tinctures, and full spectrum products. These options allow you to customize your approach to sleep improvement, whether you prefer sublingual absorption or a convenient edible format.

How else can you support your sleep?

While CBN is an excellent option for sleep support, it works best when combined with good sleep hygiene and other healthy habits. Supplements alone can’t replace the benefits of a well-rounded lifestyle. 

Here are some strategies to help you get a good night's sleep:

Maintain a consistent sleep schedule

Going to bed and waking up at the same time every day helps regulate your sleep-wake cycle. This consistency reinforces your circadian rhythm, making it easier to fall asleep and wake up feeling refreshed.

Limit evening stimulation

Avoid caffeine, bright screens, and other stimulants in the hours before bedtime. These habits can disrupt your body’s preparation for sleep, leading to sleep disturbances.

Incorporate relaxation techniques

Deep breathing, stretching, or meditation can help reduce tension and prepare your body for rest. Pairing these activities with CBN can amplify their calming effects.

Engage in regular physical activity

Exercise supports overall well-being and helps combat the inflammatory effects of a sedentary lifestyle. Just avoid vigorous workouts too close to bedtime, as they can be energizing.

Create a sleep-friendly environment

A cool, dark, and quiet room can make a significant difference in improving sleep quality. Blackout curtains, white noise machines, and breathable bedding can all contribute to a more comfortable sleep setting.

The bottom line

At Sunmed, we’re dedicated to helping you achieve your wellness goals through premium hemp-derived products. 

Our CBN products are carefully crafted to support your journey to better sleep, with full spectrum options designed to work harmoniously with your body. Each product is made with clean ingredients and undergoes rigorous third-party testing to ensure purity, consistency, and safety.

We believe in empowering you with the tools and knowledge to take control of your sleep and overall health. Whether you’re trying our CBN gummies or exploring tinctures tailored for sleep support, we’re here to guide you every step of the way. Together, we can help you prioritize rest, relaxation, and the long-term benefits of a balanced lifestyle.

*This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sources:

Cannabinol - an overview | ScienceDirect Topics

Cannabinoids and Sleep: Exploring Biological Mechanisms and Therapeutic Potentials | PMC

Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial | PMC

Melatonin: What You Need To Know | NCCIH

What Is Sleep Debt and How Do You Get Rid of It? | Mana Medical Associates

Mastering Sleep Hygiene: Your Path to Quality Sleep | Sleep Foundation