What is THCB? Origin, benefits, and risks
If you’ve looked into some of the hemp and cannabis products that have become a mainstay in the wellness world, you are likely familiar with THC and CBD, two of the main compounds derived from hemp. However, cannabinoids go far beyond these two well-known names.
THCB, a lesser-known cannabinoid, is one of several that is starting to capture interest for its unique effects.
So, what exactly is THCB? We’re here to delve into its role, where it comes from, how it works, and what you should know about its potential benefits and risks so you can feel confident in choosing the right products for your needs.
What is THCB?
THCB, or tetrahydrocannabutol, is a trace cannabinoid that was only recently discovered in 2019.
Like many cannabinoids, THCB is found in the hemp and cannabis plants, but in very small amounts — less than 1% of the plant's total composition. This makes it quite rare compared to more commonly known cannabinoids like THC or CBD.
Researchers uncovered THCB while studying other cannabinoids, including THCP, another newly discovered compound. THCB shares many similarities with THC — especially when it comes to how it may affect the body — but it also has unique properties that set it apart.
Because THCB is relatively new to the world of cannabinoid research, scientists are still learning about its full range of effects, making it an exciting but lesser-understood part of the cannabinoid family.
Understanding the chemical structure of THCB
THCB’s structure consists of 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms. What makes THCB different from THC is a small but significant variation in its molecular structure. While THC’s chemical structure includes a pentyl side chain made of five carbon atoms, THCB has a shorter butyl side chain with only four carbon atoms.
This slight difference in structure impacts how THCB interacts with the body’s endocannabinoid system (ECS), which plays a critical role in regulating a wide range of functions, including mood, sleep, appetite, and immune response.*
How does THCB compare to other cannabinoids?
While THCB shares many effects with THC, such as potential psychoactivity, its shorter side chain may make its interaction with certain receptors in the brain slightly different.*
Cannabinoids like THCB interact with this system by binding to receptors known as CB1 and CB2. THCB, like THC, has a strong affinity for CB1 receptors, which are found primarily in the brain. When THCB binds to these receptors, it can produce psychoactive effects similar to those of THC, such as feelings of euphoria or relaxation.*
What makes THCB different is how its unique butyl side chain interacts with these receptors. While research is ongoing, some researchers believe that this shorter side chain gives THCB a slightly stronger binding affinity to CB1 receptors compared to regular THC. This means that THCB may produce more pronounced psychoactive effects, even in smaller amounts.*
In terms of potency, THCB is believed to be as strong as or even stronger than THC, meaning smaller amounts of THCB may produce more intense effects. Availability is another key difference. While THC is widely available in many forms, THCB is rarer due to its limited presence in the cannabis plant, which makes it less common in wellness products.
In comparison, CBD interacts with the ECS in a different way, primarily influencing CB1 and CB2 receptors found throughout the body without directly binding to these receptors.
While THC and THCB are both psychoactive, CBD is non-psychoactive and offers different potential wellness benefits, such as promoting calm and relaxation without the intoxicating effects.*
What are the potential benefits of THCB?
While still being researched, THCB shows promise in several areas that make it an interesting cannabinoid for those looking to support their overall wellness.
Early findings suggest that THCB may help with discomfort, provide soothing effects, and offer psychoactive experiences similar to THC.
Analgesic properties
Like THC, THCB is believed to have soothing properties, meaning it can interact with cannabinoid receptors in a way that shifts how the brain perceives discomfort.*
By interacting with the body’s CB1 receptors in the brain, which help manage how we perceive discomfort, some early research suggests that THCB may offer relief from physical tension. Similar to other cannabinoids, THCB could play a role in easing discomfort and promoting a sense of relief.*
Although more studies are needed to fully understand THCB's effects, its ability to bind with CB1 receptors shows potential for those seeking natural support for occasional discomfort.*
Soothing effects
THCB may also promote relaxation and calmness.* Initial studies comparing THCB with other cannabinoids suggest that it could help support the body’s natural response to stress and tension. For those seeking to unwind or ease feelings of tension, THCB may offer a soothing effect similar to what has been observed with THC or other cannabinoids.
As with all cannabinoids, the way THCB affects each person can vary, but it has been noted to bring a sense of calmness, helping to support relaxation and overall emotional wellness.*
Psychoactive effects
THCB is a psychoactive cannabinoid, meaning it can influence mood and perception.
Similar to delta-9 THC, THCB may produce feelings of euphoria and relaxation. However, because of its unique molecular structure, some users report that THCB’s effects are slightly different, often described as more energizing and uplifting.
These effects make THCB a cannabinoid worth exploring for those looking for both mental stimulation and relaxation, though it is important to approach its use carefully due to its potency.
Are there any risks or side effects associated with THCB?
As with any cannabinoid, there are potential risks and side effects associated with THCB. Understanding these can help users make informed decisions about whether THCB is the right fit for their wellness routine.
High potency
THCB is known to be highly potent, which means it can produce strong psychoactive effects even in small amounts. This is particularly important for those unfamiliar with cannabis or hemp products.
The heightened potency of THCB can lead to stronger reactions than expected, including potential feelings of psychological discomfort, paranoia, or distress. For this reason, THCB is generally not recommended for beginners, as its intense effects could be overwhelming.
Lack of extensive research
THCB is a relatively new discovery, so research on its long-term effects is still limited. While preliminary studies are promising, the cannabinoid’s full impact is not yet fully understood.
For those interested in trying THCB, it’s essential to approach it with caution and be mindful of how your body responds. Given the novelty of this cannabinoid, it’s important to prioritize safety and be aware that more research is needed to confirm its potential benefits and risks.
Is THCB legal?
The legal status of THCB, like many cannabinoids, exists in a grey area. Under the 2018 Farm Bill in the United States, hemp-derived cannabinoids, including THCB, are federally legal as long as they contain less than 0.3% delta-9 THC by dry weight.
However, individual state laws may vary, so it’s important to check local regulations before purchasing THCB products. While THCB products derived from hemp meet federal guidelines, the legality of these products can change as laws surrounding cannabinoids evolve.
Consumers should always stay informed of the legal landscape when exploring new cannabinoids like THCB.
How to use THCB safely
To use THCB safely, it’s best to start with a low serving size and gradually increase it as you monitor your body's response. Given THCB’s potency, beginners should begin slowly to gauge their tolerance.
Since THCB can produce strong psychoactive effects, always adjust usage based on how you feel.
Choosing high-quality THCB products is essential for safety. Look for products from reputable brands that offer transparency and third-party lab testing to verify purity and potency. At Sunmed, we are committed to providing safe, reliable products.
Our hemp-derived wellness products are made from U.S.-grown industrial hemp that meets federal legal standards, and each product undergoes rigorous third-party testing to ensure quality and safety. With Sunmed, you can feel confident in the transparency and integrity of our products.
The bottom line
THCB is a minor cannabinoid with unique properties, offering potential benefits such as discomfort relief and psychoactive effects similar to THC. However, more studies are needed to fully understand its long-term effects. THCB is found in trace amounts in cannabis and hemp plants, making it relatively rare in isolated form.
When exploring THCB, it’s important to use caution, especially for those new to cannabinoids. Start with small serving sizes and prioritize products from reputable brands that focus on safety and transparency.
At Sunmed, we are committed to providing wellness-focused, hemp-derived products that meet the highest standards. Explore our full range of high-quality, hemp-derived wellness products, all backed by third-party testing, to support your wellness journey with confidence.
*This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Sources:
The endocannabinoid system: Essential and mysterious | Harvard Health
Endocannabinoid Binding to the Cannabinoid Receptors: What Is Known and What Remains Unknown | PMC