Caryophyllene: What It Is, Properties, and More

Caryophyllene is a terpene that can help promote mental clarity and physical wellness. Learn about the benefits and how it works with Sunmed.

Caryophyllene: What It Is, Properties, and More
minute read

Key Takeaways:

  • Caryophyllene is a naturally occurring terpene found in hemp, black pepper, and other plants, known for its spicy, earthy scent.
  • It’s unique because it can interact directly with the body’s endocannabinoid system (ECS), acting in some ways like a cannabinoid.
  • Early research suggests caryophyllene may help promote calm, balance, and emotional wellness as part of the body’s natural processes.

Terpenes are the natural compounds that give plants their distinct scents and flavors. Beyond providing a plant’s unique aroma, they also contribute to the plant’s overall wellness benefits. 

One of the most studied terpenes is caryophyllene, known for its peppery aroma and its ability to interact directly with the body’s internal systems. Researchers continue to study this spicy terpene for its potential to support balance and emotional well-being.

What is caryophyllene?

Caryophyllene is a terpene found not only in the hemp and cannabis plant, but also in spices and herbs such as black pepper, cloves, cinnamon, and rosemary. It gives these plants their signature warm and slightly spicy aroma.

What makes caryophyllene stand out is its structure. Most terpenes interact with the body indirectly, but caryophyllene has the rare ability to bind to CB2 receptors in the endocannabinoid system (ECS). 

This means it can influence certain biological functions connected to balance and wellness, making it both a terpene and a cannabinoid-like compound.

How does caryophyllene interact with the endocannabinoid system?

The ECS plays a key role in helping the body maintain homeostasis — a state of internal balance that affects mood, stress, sleep, and immune function. CB2 receptors, one part of this system, are mostly found in immune tissues.

When caryophyllene binds to these CB2 receptors, it may help the body regulate its natural stress response and maintain equilibrium. Early studies suggest this terpene might support relaxation and emotional wellness by helping calm overactive signals in the body’s internal systems. 

Because it doesn’t interact with CB1 receptors in the brain, caryophyllene does not produce any psychoactive effects.

What are the benefits of caryophyllene? 

Preliminary research points to several ways caryophyllene may support well-being:

  • Promotes relaxation and emotional balance
  • Supports the body’s natural response to stress
  • Encourages overall wellness and calm

Scientists are still exploring exactly how these effects occur, but evidence suggests caryophyllene works in harmony with other hemp compounds to support a well-rounded wellness experience. 

While not a treatment or cure for any condition, it’s an exciting area of study for those interested in plant-based wellness.

The bottom line

Caryophyllene highlights how nature’s compounds can work with the body’s own systems to promote balance and calm. 

Looking to incorporate caryophyllene into your wellness routine? As a naturally occurring compound in the hemp plant, caryophyllene can be found in full spectrum and broad spectrum CBD products, where it works synergistically with other plant parts to promote balance and support overall well-being.

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FAQs

What makes caryophyllene different from other terpenes?

Caryophyllene is unique because it directly interacts with the body’s CB2 receptors, a feature most terpenes don’t share. This gives it both aromatic and potential functional properties.

Can caryophyllene make you feel relaxed?

Caryophyllene may help the body maintain calm and balance by supporting its natural stress response. Its grounding properties make it a popular terpene in many hemp-derived products.

Is caryophyllene only found in hemp?

No. Caryophyllene also occurs naturally in black pepper, cloves, basil, cinnamon, and hops. Its spicy, woody aroma makes it easy to recognize across many plants.

Sources:

(-)-Caryophyllene | C15H24 | CID 5281515 | PubChem

β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice | PubMed

The endocannabinoid system: Essential and mysterious | Harvard Health

Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders | PMC